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Meanwhile, changes in quality-of-life scores measured by the Short Form-36 (SF-36) physical and mental components were small and not clinically significant across groups [1]

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Interest broadened sharply after Yang and colleagues (Cell, 2014) used targeted metabolomic profiling across twelve ferroptosis-inducing small molecules and found that glutathione depletion converges on inactivation of the selenoenzyme glutathione peroxidase 4, placing glutathione availability directly upstream of iron-dependent lipid peroxidation

Pradalier et al