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Medications that have been used in the past used include conventional lipid lowering therapies like statins (atorvastatin, rosuvastatin, simvastatin), fibrates (gemfibrozil) but they dont work well

As a result of the study, it was observed that the administered melatonin had a beneficial effect on the lipid profile, the percentage of fat present in the abdominal cavity, the body weight of the rats, and also the overall insulin concentration in the body

Short-term benefit of flumazenil with the absence of prolonged effects is not unsurprising given its short elimination half-life (0.71.3 h), and thus it is not currently advocated for routine clinical use to treat HE

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