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Metformin has also been shown to improve insulin secretion from rat islets chronically exposed to high levels of NEFA or glucose [21], suggesting a direct effect on pancreatic beta cells independent of its glucose-lowering action

This multi-receptor targeting approach potentially offers a more comprehensive metabolic effect by enhancing insulin sensitivity, reducing hunger, and increasing energy expenditure through glucagon activity

However, the mouth's harsh environmentsaliva, pH changes, and enzymatic breakdowndestroys a large portion of the peptide before it reaches systemic circulation