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The genes involved in ASD are variable and diverse, but mutations in genes related to the mammalian target of rapamycin (mTOR) pathway, including NF1 (59), PTEN (60), TSC1 (61), TSC2 (62), eIF4E (63), FMRP (64), are among those most widely associated with ASD (Figure 2)

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10.1056/NEJMoa1607141 N Engl J Med

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