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The pioneer work of Wilcken and Wilcken (1976) showed an abnormal increase in homocysteine after an oral methionine load in patients with coronary artery disease

Arch Neurol 46:543548

For more information about FDAs posting of comments to public dockets, see 80 FR 56469, September 18, 2015, or access the information at: Federal Register/Vol

Regarding the safety of H 2 use, although in most of the existing studies, no severe adverse reactions directly caused by H 2 have been reported, H 2 is a natural product of anaerobic bacteria metabolism in the intestines

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